Articles: sars-cov-2.
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Pediatr Crit Care Me · Nov 2022
Characteristics and Outcomes of Critically Ill Children With Multisystem Inflammatory Syndrome.
To characterize the prevalence of pediatric critical illness from multisystem inflammatory syndrome in children (MIS-C) and to assess the influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain on outcomes. ⋯ Overall mortality from MIS-C was low, but the disease burden was high. There was a peak in MIS-C cases during Q1 of 2021, following a shift in viral strains in Q1 of 2021. However, an improvement in MIS-C outcomes starting in Q4 of 2020 suggests that viral strain was not the driving factor for outcomes in this population.
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T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. ⋯ Our findings suggest prolonged T-cell exhaustion is an important immunological sequela, potentially related to long-term outcomes after severe COVID-19.
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Increasingly, climate change policies are emerging across Europe. Policies addressing adaptation (adjusting the effects of climate change on public health) are being implemented after the COVID-19 pandemic. This study aims to identify issues in climate adaptation implementation for public health and understand the health implications from responses after COVID-19. ⋯ This project has received part-funding from the Enhancing Belmont Research Action to support EU policy making on climate change and health project, which is part of the EU's Horizon 2020 research and innovation programme (grant agreement number 101003966). The research was part-funded by the National Institute for Health Research Health Protection Research Unit in Environmental Change and Health at the London School of Hygiene and Tropical Medicine in partnership with Public Health England, the Met Office, and University College London (grant number PHSEZT6210). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, the Department of Health and Social Care or PHE.
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Acta clinica Croatica · Nov 2022
Observational StudyNEUROLOGICAL SYMPTOMS COMMON IN COVID-19 PATIENTS: A RETROSPECTIVE OBSERVATIONAL STUDY.
In December 2019, a novel coronavirus outbreak spread rapidly all over the world. The virus is known to be neuroinvasive, but much is still unknown. In this study, we aimed to present the main neurologic symptoms in patients who were diagnosed with coronavirus disease 2019 (COVID-19). ⋯ Headache in particular was the most common symptom in our population. In patients with respiratory system findings, the detection of certain neurological symptoms such as smell-taste impairments, impaired consciousness, and sleep disorders were more common. We concluded that COVID-19 patients should be approached in a more holistic way, taking the nervous system into account.
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To investigate the emergent mutations involved in the evolutionary stages of the virus for better management of pandemic. ⋯ The current study provides useful information for further experimental investigation of mutation's effects on virus transmission, severity, and vaccine efficacy.