Knowledge

Collections of articles, notes and knowledge from the metajournal community.

COVID-19 and mRNA Vaccines

Covid
- Letter
  
  Neutralizing Activity of BNT162b2-Elicited Serum.
  
  N. Engl. J. Med. 2021 Apr 15; 384 (15): 146614681466-1468.
  
  The Pfizer–BioNTech COVID-19 vaccine was 91% effective in preventing infection with SARS-CoV-2 in phase 3 trials.
  pearl
- Randomized Controlled Trial
  
  Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
  
  N. Engl. J. Med. 2020 Dec 31; 383 (27): 260326152603-2615.
- Comparative Study
  
  SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
  
  Immunity. 2020 Dec 15; 53 (6): 1281-1295.e5.
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Does zinc have antiviral activity?

Covid Drugs Infectious diseases
- Review
  
  The Role of Zinc in Antiviral Immunity.
  
  Adv Nutr. 2019 Jul 1; 10 (4): 696-710.
- Review
  
  Bioinorganic Chemistry of Zinc in Relation to the Immune System.
  
  Chembiochem. 2021 Dec 10: e202100554.
- Review
  
  Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review).
  
  Int. J. Mol. Med. 2020 Jul 1; 46 (1): 17-26.
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Reducing health-system harm: Safety I vs Safety II

Safety
- Editorial
  
  The harms of promoting 'Zero Harm'.
  
  BMJ Qual Saf. 2020 Jan 1; 29 (1): 4-6.
- Review
  
  Managing risk in hazardous conditions: improvisation is not enough.
  
  BMJ Qual Saf. 2020 Jan 1; 29 (1): 60-63.
  
  To improve overall safety and reduce harm, focus should be on reducing risk instead of eliminating harm.
  pearl
- Review
  
  Safety-II and resilience: the way ahead in patient safety in anaesthesiology.
  
  Curr Opin Anaesthesiol. 2015 Dec 1; 28 (6): 735-9.
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Surgical safety checklists

Cognitive aids Decision making
The World Health Organisation's Surgical Safety Checklist has been adopted and implemented by many hospitals throughout the world: from large tertiary teaching hospitals in wealthy countries, to small hospitals in low-resource settings.

The benefits to each hospital however are likely not the same. Does the WHO SSC implemented in a hospital that already has a 'Time Out' process bring the same benefit, if any, as to a hospital for which the checklist was completely new? Possibly not.

Several studies across a wide range of health systems have shown conflicting results in terms of reducing morbidity, mortality and length of stay.
summary

...and 1 more note
- Randomized Controlled Trial
  
  Effect of the World Health Organization checklist on patient outcomes: a stepped wedge cluster randomized controlled trial.
  
  Ann. Surg.. 2015 May 1;261(5):821-8.
  
  Implementing the WHO Safe Surgery Checklist may reduce morbidity, length of stay and mortality, although many questions remain.
  pearl
- Article
  
  Surgical safety checklists: do they improve outcomes?
  
  Br J Anaesth. 2012 Jul 1;109(1):47-54.
- Clinical Trial
  
  Surgical safety checklist: implementation in an ambulatory surgical facility.
  
  Can J Anaesth. 2013 Jun 1; 60 (6): 528-38.
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Read Articles

Collection
- Observational Study
  
  Association Between Lower Preoperative Cognition With Intraoperative Electroencephalographic Features Consistent With Deep States of Anesthesia in Older Patients: An Observational Cohort Study.
  
  Anesth. Analg. 2021 Jul 1; 133 (1): 205214205-214.
  
  Older patients with low pre-operative cognitive performance may inadvertently be receiving a relative overdose during volatile general anaesthesia.
  pearl
- Review
  
  Airborne transmission of severe acute respiratory syndrome coronavirus-2 to healthcare workers: a narrative review.
  
  Anaesthesia. 2020 Aug 1; 75 (8): 1086-1095.
  
  Transmission of SARS-CoV-2 should be conceptualised as a spectrum of risk where time exposed may be the dominant factor.
  pearl
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Knowledge

COVID-19 and mRNA Vaccines

Does zinc have antiviral activity?

Reducing health-system harm: Safety I vs Safety II

Surgical safety checklists

Read Articles

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