The Veterinary clinics of North America. Food animal practice
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Vet. Clin. North Am. Food Anim. Pract. · Mar 2015
ReviewClinical pharmacology of analgesic drugs in cattle.
Providing pain relief in cattle is challenging. In the absence of labeled drugs, the Animal Medicinal Drug Use Clarification Act regulates the extralabel drug use of analgesics in cattle within the United States. ⋯ This article reviews the commonly used analgesics investigated in cattle including local anesthetics, nonsteroidal anti-inflammatory drugs, opioids, α2-agonists, N-methyl-d-aspartate receptor antagonists, and gabapentin. These compounds are examined with respect to evidence of analgesia in cattle during pain states.
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Vet. Clin. North Am. Food Anim. Pract. · Jul 2014
ReviewAcid-base assessment: when and how to apply the Henderson-Hasselbalch equation and strong ion difference theory.
The Henderson-Hasselbalch equation is probably the most famous equation in biology but is more descriptive than mechanistic. The traditional approach to acid-base assessment using the Henderson-Hasselbalch equation provides a clinically useful and accurate method when plasma protein concentrations are within the reference range. The simplified strong ion approach is a mechanistic acid-base model that can provide new insight into complicated acid-base disturbances. The simplified strong ion approach should be used to evaluate acid-base balance whenever plasma protein concentrations are abnormal.
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The dysnatremias are defined as abnormalities in serum sodium concentration. Depending on the magnitude and duration of the sodium abnormality and the nature of any concurrent or primary disease, hypernatremia and hypernatremia may result in no consequences, subclinical impairment of health and productivity, or severe clinical disease. Dysnatremias can be the sequelae to diseases or environmental conditions that promote fluid gain or loss from the body, as well as medical interventions that add excessive amounts of sodium or water to the extracellular fluid. Extreme, sustained dysnatremia may result in central nervous system dysfunction and death.
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Vet. Clin. North Am. Food Anim. Pract. · Mar 2013
ReviewBovine dehorning: assessing pain and providing analgesic management.
Dehorning or disbudding in cattle is performed for a variety of reasons using various methods. Pain associated with this procedure has been mostly evaluated through behavioral, physiologic, and neuroendocrine changes following dehorning. ⋯ The administration of sedatives with analgesic properties has been indicated in the attenuation of the acute phase of pain associated with dehorning. Following a literature review, this article recommends a multimodal approach to analgesia for dehorning procedures, including the use of a local anesthetic and anti-inflammatory and, when possible, a sedative-analgesic.
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Vet. Clin. North Am. Food Anim. Pract. · Mar 2013
ReviewA review of analgesic compounds used in food animals in the United States.
Extralabel drug use for pain relief in the United States is regulated under the Animal Medicinal Drug Use Clarification Act. Agents that may provide analgesia in livestock include local anesthetics, nonsteroidal antiinflammatory drugs, opioids, α2-agonists, and N-methyl-d-aspartate receptor antagonists. The challenges associated with providing pain relief in food animals and the salient pharmacokinetic and pharmacodynamic features of the analgesic compounds that could potentially be used in livestock are reviewed. The potential use of novel agents such as bicarbonate, magnesium, ethanol, and gabapentin to augment analgesia is also discussed.